Another Cause of Hair Loss: Details on PGD2 or Prostaglandin D2

If you are suffering from excessive hair loss to a point of permanently donning bald spots on your head, finding a cure seems to be a very tempting solution. But this is something that is no longer new to us since there are a number of hair loss medications that are available in the market today.

However to some unfortunate few, this seems to be ineffective for them leaving these individuals to become helpless and desperate. But there is good news today after researchers found another culprit to hair loss, which is PGD2 or Prostaglandin D2.

Unlike DHT (dihydrotestosterone) which is a more active form of hormone that causes hair loss, PGD2 is a protein that can be found in certain parts of the body, most particularly the scalp.

In a research study that was headed by Dr. Gerorge Cotsarelis, who is the head of the dermatological department in the University of Pennsylvania, they found that PGD2 is also causing hair loss in males. They were able to reach this conclusion after testing 250 genes that were implicated in excessive hair loss.

What they did is that they took scalp samples in the balding areas of five men, and then also took another set of samples from their unaffected scalp areas for comparison. After the tests were done, they found out that those bald spots contain thrice the amount of PGD2 than those hairy areas. This led them to conclude that PGD2 can be another cause for hair loss.

PGD2 isn’t really some random protein that springs into your system and leaves this destructive result to your hair. PGD2 is actually important for bodily functions such as the promotion of cell growth, smooth muscle contraction and even sleep regulation. But research using the stem cells of the underlying hair follicles in the affected scalp revealed that it halts their normal growth and maturation. This also lead the researchers to believe that what the scalp needs is something that will go against the hindrance to restore the normal life cycle of these hairs which are just staying dormant below the scalp.

That is why Dr. Cotsarelis deem it necessary to urge companies to develop drugs that particularly cater to targeting PGD2.

Now, the irony here is that PGE2 and PGF2 which are also related forms of prostaglandins promote hair growth. In fact, they are even included in formulating popular hair loss drugs such as Rogaine and Latisse. It seems that PGD2 goes against the grain and create its unattractive effects.

But the good thing about this is that there are already PGD2-inhibting drugs that are out in the market. However, they are marketed for other purposes, such as treating asthma attacks and allergic reactions. Researchers, particularly Dr. Cotsarelis believed that these drugs can be formulated into a lotion to be applied on the scalp to stop progressive hair loss and promote hair growth.

Tests also showed that these same these drugs which inhibit PGD2 levels can also be applicable to women who are also suffering from hair loss.

This new discovery will certainly revolutionize hair loss treatment, and can offer more options for some who may not be responsive with the typical pharmaceutical solutions.

To know best on how to manage your hair loss, always approach your doctor or dermatologist first. In that way you can be properly assessed and an appropriate treatment can be given.